Pasteurella

CASE 1

• A 24 year old man has warmth, swelling, and tenderness progressing up his right arm over the past 12 hours. The previous day he visited the home of a friend. While trying to pick up his friend's pet cat, he was bitten on the right wrist. There was a deep puncture wound. Initially, he was concerned about the possibility of rabies, but he learned that the cat had recently received rabies vaccine. Within a day, pain and redness began at the bite site and began to spread up the arm. The patient had some flucloxacillin (an anti-staphyloccal penicillin) left over from a treatment he received for a skin infection, so he began taking it. It did not seen to slow the progression of his infection, so he came to the Emergency Center at KATH.

• On physical examination, his temperature is 38.3 degrees. The only significant finding is on right upper extremity where there is hyperemia of the skin, warmth, swelling, and tenderness to the mid-humerus. There is also some tenderness in the right axilla.

• The white blood cell count is 15,500 with 92% neutrophils. A blood culture is obtained before the patient is treated with ampicillin-sulbactam intravenously. In 36 hours, it grows Pasteurella multocida. The cellulitis and fever slowly resolved, and the patient was given a 14-day course of an oral antibiotic to complete treatment. He was instructed to return for an xray of his wrist at the end of treatment.

Questions:

    1. What was the source of this organism?
    2. What may have happened to this patient had he not received treatment?
    3. Why was flucloxacillin not effective against this pathogen?
    4. Why was the patient asked to return for an xray in 2 weeks (hint: consider the shape of the cat's teeth)?